Overview

Location [1]
12q13.12
Protein [2]
Cyclic AMP-dependent transcription factor ATF-1
Synonyms [1]
TREB36, FUS/ATF-1, EWS-ATF1

Activating transcription factor 1 (ATF1) is a gene that encodes a transcription factor protein that functions in regulating the expression of downstream target genes that affect growth, survival, and other cellular activities. Fusions, missense mutations, and silent mutations are observed in cancers such as breast cancer, intestinal cancer, and ovarian cancer.

ATF1 is altered in 0.61% of all cancers.

Significance of ATF1 in Diseases

Clear Cell Sarcoma Of Soft Tissue +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.