5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) is a gene that encodes a catalytic protein that catalyzes the final two steps of the de novo purine biosynthetic pathway. Fusions, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as lung cancer, ovarian cancer, and skin cancer.
ATIC is altered in 0.08% of all cancers with lung adenocarcinoma, acute myeloid leukemia, cancer of unknown primary, diffuse large B-cell lymphoma, not otherwise specified, and glioblastoma having the greatest prevalence of alterations .
The most common alteration in ATIC is ATIC-ALK Fusion (0.08%) .
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