Overview

Aurora kinase A (AURKA) is a gene that encodes a protein that functions as a cell cycle-regulated kinase that regulates microtubule formation during mitosis. Missense, nonsense, and silent mutations are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

AURKA is altered in 1.36% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, lung adenocarcinoma, invasive breast carcinoma, and rectal adenocarcinoma having the greatest prevalence of alterations [3].

The most common alterations in AURKA are AURKA Amplification (0.93%), AURKA Mutation (0.55%), AURKA Fusion (0.03%), AURKA R343W (0.02%), and AURKA S249L (0.02%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.