Overview

Location [1]
17p13.1
Pathway
Cell cycle control
Protein [2]
Aurora kinase B
Synonyms [1]
ARK2, AIM1, PPP1R48, aurkb-sv2, AIM-1, ARK-2, AIK2, AurB, aurkb-sv1, STK5, IPL1, STK-1, STK12

Aurora kinase B (AURKB) is a gene that encodes a protein that is a member of the aurora kinase serine/threonine kinase family. The protein functions in the process of chromosomal segregation during mitosis and meiosis. Missense and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

AURKB is altered in 0.76% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, prostate adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

AURKB GENIE Cases - Top Diseases

The most common alterations in AURKB are AURKB Mutation (0.47%), AURKB Loss (0.25%), AURKB Amplification (0.09%), AURKB R248H (0.02%), and AURKB M58I (0.05%) [3].

AURKB GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.