Location [1]
Protein [2]
Synonyms [1]

Axin 2 (AXIN2) is a gene that encodes a protein that functions in the regulation of the stability of beta-catenin in the WNT signaling pathway. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions, are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

AXIN2 is altered in 2.40% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, and invasive breast carcinoma having the greatest prevalence of alterations [3].

AXIN2 GENIE Cases - Top Diseases

The most common alterations in AXIN2 are AXIN2 Amplification (0.58%), AXIN2 Loss (0.04%), AXIN2 Fusion (0.11%), AXIN2 A758V (0.01%), and AXIN2 D159Y (0.03%) [3].

AXIN2 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.