Location [1]
Protein [2]
Tyrosine-protein kinase receptor UFO
Synonyms [1]
JTK11, ARK, Tyro7, UFO

AXL receptor tyrosine kinase (AXL) is a gene that encodes a protein that belongs to the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase family. The protein functions in cell signal transduction by binding to vitamin K-dependent protein growth arrest specific 6 (Gas6). Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer.

AXL is altered in 2.00% of all cancers with colon adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, endometrial endometrioid adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

AXL GENIE Cases - Top Diseases

The most common alterations in AXL are AXL Mutation (1.69%), AXL Amplification (0.21%), AXL H292fs (0.09%), AXL Loss (0.09%), and AXL Fusion (0.04%) [3].

AXL GENIE Cases - Top Alterations

Significance of AXL in Diseases

Malignant Solid Tumor +

Cancer +

Non-Small Cell Lung Carcinoma +

Hepatoblastoma +

Alveolar Soft Part Sarcoma +

Head And Neck Squamous Cell Carcinoma +

Wilms Tumor +

Prostate Carcinoma +

Rhabdomyosarcoma +

Thyroid Gland Medullary Carcinoma +

Osteosarcoma +

Adrenal Cortex Carcinoma +

Ewing Sarcoma +

Soft Tissue Sarcoma +

Renal Cell Carcinoma +

Acute Myeloid Leukemia +

Hepatocellular Carcinoma +

Acute Promyelocytic Leukemia +

Clear Cell Sarcoma Of Soft Tissue +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.