Overview

Location [1]
19q13.2
Synonyms [1]
Tyro7, ARK, UFO, JTK11

AXL receptor tyrosine kinase (AXL) is a gene that encodes a protein that belongs to the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase family. The protein functions in cell signal transduction by binding to vitamin K-dependent protein growth arrest specific 6 (Gas6). Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer.

Significance of AXL in Diseases

Malignant Solid Tumor +

Cancer +

Non-Small Cell Lung Carcinoma +

Acute Myeloid Leukemia +

Acute Promyelocytic Leukemia +

Adrenal Cortex Carcinoma +

Alveolar Soft Part Sarcoma +

Clear Cell Sarcoma Of Soft Tissue +

Ewing Sarcoma +

Head And Neck Squamous Cell Carcinoma +

Hepatoblastoma +

Hepatocellular Carcinoma +

Osteosarcoma +

Prostate Carcinoma +

Renal Cell Carcinoma +

Rhabdomyosarcoma +

Soft Tissue Sarcoma +

Thyroid Gland Medullary Carcinoma +

Wilms Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.