BCL2-like 1 (BCL2L1) is a gene that encodes a protein that is a member of the BCL-2 family. The protein functions in the regulation of outer mitochondrial membrane channel (VDAC) opening—a mechanism that regulates mitochondrial membrane potential and, ultimately, the induction of apoptosis. Fusions, rearrangements, Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, esophageal cancer, and lung cancer.
Modified: July 1, 2015
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