Location [1]
Protein [2]
BCL-6 corepressor-like protein 1
Synonyms [1]
CXorf10, SHUVER, BCoR-L1

BCL6 co-repressor-like 1 (BCORL1) is a gene that encodes a transcriptional co-repressor protein of DNA. Missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame deletions are observed in cancers such as colorectal cancer, myelodysplastic syndromes, skin cancer, and stomach cancer.

BCORL1 is altered in 2.11% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and melanoma having the greatest prevalence of alterations [3].

BCORL1 GENIE Cases - Top Diseases

The most common alterations in BCORL1 are BCORL1 G883E (0.19%), BCORL1 R784* (0.05%), BCORL1 L1624I (0.05%), BCORL1 R1196* (0.04%), and BCORL1 Loss (0.05%) [3].

BCORL1 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.