BCR-ABL1
BCR-ABL1 is a fusion gene usually formed via a t(9;22) (q34;q11) translocation (Faderl et al. 1999). This translocation results in the Philadelphia chromosome. In rare cases lacking the traditional t(9;22) translocation, other translocations result in the creation of the BCR-ABL1 fusion gene. These sometimes involve multiple chromosomes.
BCR-ABL1 is present in all cases of chronic myeloid leukemia, but it is also involved in other cancers. These include pediatric B-cell acute lymphoblastic leukemia (3-5%), adult B-cell acute lymphoblastic leukemia (25-30%), acute myeloid leukemia (rare), and T-cell acute lymphoblastic leukemia (rare; De Braekeleer et al. 2011).
ABL1 kinase inhibitors have been developed as targeted therapies against BCR-ABL1 positive malignancies.
Related Pathways
Contributors:
Aaron Shaver, M.D., Ph.D., Madan Jagasia, M.B.B.S., M.S.
Suggested Citation:
Shaver, A., Jagasia, M. 2015.
BCR-ABL1.
My Cancer Genome
https://www.mycancergenome.org/content/gene/bcr-abl1/
(Updated December 2015)
Modified:
December 7, 2015
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