Biomarkers /
BIRC2
Overview
Baculoviral IAP repeat containing 2 (BIRC2) is a gene that encodes a protein that belongs to a family of proteins that functions in the inhibition of apoptosis by binding to TRAF1 and TRAF2 (tumor necrosis factor receptor-associated factors). Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
BIRC2 is altered in 0.04% of all cancers with high grade ovarian serous adenocarcinoma, colon adenocarcinoma, cervical squamous cell carcinoma, desmoplastic melanoma, and leiomyosarcoma having the greatest prevalence of alterations [3].
The most common alterations in BIRC2 are BIRC2 H269R (0.22%), BIRC2 M181V (0.39%), BIRC2 M237V (0.22%), BIRC2 M277L (0.39%), and BIRC2 N405D (7.69%) [3].
Clinical Trials
Significance of BIRC2 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.