Overview

Location [1]
11q22.2
Synonyms [1]
MALT2, CIAP2, AIP1, RNF49, c-IAP2, API2, HIAP1, IAP-1, MIHC, HAIP1

Baculovial IAP repeat containing 3 (BIRC3) is a gene that encodes encodes the protein cellular inhibitor of apoptosis protein 2 (cIAP2), which inhibits apoptosis. BIRC3 is localized to chromosome 11q22, whose deletion is associated with high risk disease in patients with chronic lymphocytic leukemia. BIRC3 mutations are observed in <5% of patients with CLL (PMID: 24943832; PMID: 24597984; PMID: 24217197; PMID: 22308293; PMID: 25605254), ~11% of patients with Splenic marginal zone lymphoma (PMID: 21881048) and 6-10% of mantle cell lymphoma cases (PMID: 24362935).

Biomarker-Directed Therapies

Significance of BIRC3 in Diseases

Marginal Zone Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Adult T-Cell Acute Lymphoblastic Leukemia +

Anaplastic Large Cell Lymphoma +

Angioimmunoblastic T-Cell Lymphoma +

Cancer +

Cervical Carcinoma +

Chronic Lymphocytic Leukemia +

Chronic Myeloid Leukemia +

Diffuse Large B-Cell Lymphoma +

Enteropathy-Associated T-Cell Lymphoma +

Follicular T-Cell Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Hepatosplenic T-Cell Lymphoma +

Lymphoma +

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma +

Multiple Myeloma +

Mycosis Fungoides +

Myelodysplastic Syndromes +

Nasal Type Extranodal NK/T-Cell Lymphoma +

Nodal Peripheral T-Cell Lymphoma With TFH Phenotype +

Peripheral T-Cell Lymphoma +

Peripheral T-Cell Lymphoma, Not Otherwise Specified +

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma +

Prolymphocytic Leukemia +

Sezary Syndrome +

Subcutaneous Panniculitis-Like T-Cell Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.