Location [1]
Protein [2]
Bromodomain-containing protein 4
Synonyms [1]

Bromodomain containing 4 (BRD4) is a gene that encodes a protein that associates with human RING3 protein and chromosomes during mitosis. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

BRD4 is altered in 2.38% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

BRD4 GENIE Cases - Top Diseases

The most common alterations in BRD4 are BRD4 Mutation (1.85%), BRD4 Amplification (0.30%), BRD4 Fusion (0.08%), BRD4-NOTCH3 Fusion (0.04%), and BRD4 Loss (0.03%) [3].

BRD4 GENIE Cases - Top Alterations

Significance of BRD4 in Diseases

Urothelial Carcinoma +

Malignant Solid Tumor +

Bladder Carcinoma +

Lymphoma +

Central Nervous System Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.