Overview

Location [1]
12q21.33
Protein [2]
Protein BTG1
Synonyms [1]
APRO2

B-cell translocation gene 1, anti-proliferative (BTG1) is a gene that encodes a protein that belongs to an anti-proliferative gene family. The protein functions in the regulation of cell growth and differentiation by acting as a coactivator of cell differentiation. Fusions, missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as hematopoietic and lymphoid cancers, kidney cancer, and lung cancer.

BTG1 is altered in 0.82% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, follicular lymphoma, conventional glioblastoma multiforme, lung adenocarcinoma, and high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements having the greatest prevalence of alterations [3].

BTG1 GENIE Cases - Top Diseases

The most common alterations in BTG1 are BTG1 E46D (0.11%), BTG1 L37V (0.14%), BTG1 S43N (0.10%), BTG1 Amplification (0.07%), and BTG1 P3L (0.09%) [3].

BTG1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.