Overview

Location [1]
10q24.32
Pathways
Beta-Catenin/WNT signaling, Protein degradation/ubiquitination
Protein [2]
F-box/WD repeat-containing protein 1A
Synonyms [1]
FBXW1, FWD1, BETA-TRCP, bTrCP, FBW1A, betaTrCP, bTrCP1, FBXW1A

Beta-transduction repeat containing E3 ubiquitin protein ligase (BTRC) is a gene that encodes a protein that is a member of the F-box protein family that functions in phosphorylation-dependent ubiquitination. The protein participates in the degradation of CD4 and ubiquitinates phosphorylated NFKBIA. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Significance of BTRC in Diseases

Esophageal Squamous Cell Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Breast Carcinoma +

Cervical Squamous Cell Carcinoma +

Colorectal Carcinoma +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Gastric Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Malignant Solid Tumor +

Melanoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.