Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) is a gene that encodes a trifunctional enzymatic protein that functions in the pyrimidine biosynthesis pathway. The protein is regulated by the MAP kinase pathway. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions and deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
Modified: July 1, 2015
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