Location [1]
Protein [2]
Caspase-8 subunit p10
Synonyms [1]

Caspase 8, apoptosis-related cysteine peptidase (CASP8) is a gene that encodes a protein that belongs to the cysteine-aspartic acid protease (caspase) family. The protein functions in the execution-phase of apoptosis induced by Fas. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CASP8 is altered in 1.49% of all cancers with colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

CASP8 GENIE Cases - Top Diseases

The most common alterations in CASP8 are CASP8 Mutation (1.13%), CASP8 Amplification (0.06%), CASP8 R68Q (0.05%), CASP8 Loss (0.04%), and CASP8 E180* (0.03%) [3].

CASP8 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.