Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
4q27
Pathway
Cell cycle control
Protein [2]
Cyclin-A2
Synonyms [1]
CCNA, CCN1

Cyclin A2 (CCNA2) is a gene that encodes a member of the cyclin family that functions as a regulator of cyclin-dependent kinases (CDKs). Cyclin A2 is expressed in all tissues. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as cervical cancer, endometrial cancer, and intestinal cancer.

Significance of CCNA2 in Diseases

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.