Associated Genetic Biomarkers
Associated Diseases
Associated Pathways


Location [1]
Cell cycle control
Protein [2]
G2/mitotic-specific cyclin-B3
Synonyms [1]

Cyclin B3 (CCNB3) is a gene that encodes a member of the cyclin family that functions as a regulator of cyclin-dependent kinases (CDKs). Cyclin B3 is involved in the regulation of the cell cycle. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, lung cancer, and skin cancer.

CCNB3 is altered in 0.03% of all cancers with lung adenocarcinoma, round cell sarcoma, acute myeloid leukemia, breast invasive lobular carcinoma, and cancer of unknown primary having the greatest prevalence of alterations [3].

CCNB3 GENIE Cases - Top Diseases

The most common alteration in CCNB3 is CCNB3-BCOR Fusion (0.00%) [3].

CCNB3 GENIE Cases - Top Alterations

Significance of CCNB3 in Diseases

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.