Overview

Location [1]
19q12
Pathway
Cell cycle control
Protein [2]
G1/S-specific cyclin-E1
Synonyms [1]
pCCNE1, CCNE

Cyclin E1 (CCNE1) is a gene that encodes a protein that is a member of the cyclin family. The protein complexes with and functions as a regulator of CDK2. The activity of this protein complex is required for cell cycle G1/S transition. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, lung cancer, and stomach cancer.

CCNE1 is altered in 2.24% of all cancers with non-small cell lung carcinoma, ovarian neoplasm, breast carcinoma, uterine corpus neoplasm, and colorectal adenocarcinoma having the greatest prevalence of alterations [3].

CCNE1 GENIE Cases - Top Diseases

The most common alterations in CCNE1 are CCNE1 Amplification (1.66%), CCNE1 Mutation (0.60%), CCNE1 A178V (0.01%), CCNE1 A214V (0.01%), and CCNE1 D130A (0.01%) [3].

CCNE1 GENIE Cases - Top Alterations

Significance of CCNE1 in Diseases

Malignant Solid Tumor +

Non-Hodgkin Lymphoma +

High Grade Ovarian Serous Adenocarcinoma +

Esophageal Carcinoma +

Osteosarcoma +

Gastric Carcinoma +

Anal Carcinoma +

Breast Carcinoma +

Leiomyosarcoma +

Cervical Carcinoma +

Soft Tissue Sarcoma +

Colorectal Carcinoma +

Germ Cell Tumor +

Histiocytic And Dendritic Cell Neoplasm +

Penile Carcinoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.