Overview

Location [1]
8q22.1
Pathway
Cell cycle control
Protein [2]
G1/S-specific cyclin-E2
Synonyms [1]
CYCE2

Cyclin E2 (CCNE2) is a gene that encodes a member of the cyclin family that functions as a regulator of cyclin-dependent kinases (CDKs). Cyclin E2 is involved in the regulation of the cell cycle and functions as a regulatory subunit of CDK2. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Significance of CCNE2 in Diseases

Malignant Solid Tumor +

Non-Hodgkin Lymphoma +

Breast Carcinoma +

Colorectal Carcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Germ Cell Tumor +

Histiocytic And Dendritic Cell Neoplasm +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.