Location [1]
Protein [2]
B-cell receptor CD22
Synonyms [1]

CD22 molecule (CD22) is a gene that encodes a protein that mediates interactions between B-cells. The protein may also function in the localization of B-cell in the lymphoid tissues. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

CD22 is altered in 2.14% of all cancers with colon adenocarcinoma, lung adenocarcinoma, melanoma, astrocytoma, and combined hepatocellular carcinoma and cholangiocarcinoma having the greatest prevalence of alterations [3].

CD22 GENIE Cases - Top Diseases

The most common alterations in CD22 are CD22 Mutation (2.08%), CD22 A186V (0.16%), CD22 A798V (0.16%), CD22 D259Y (0.08%), and CD22 D436Y (0.08%) [3].

CD22 GENIE Cases - Top Alterations

Significance of CD22 in Diseases

B-Cell Acute Lymphoblastic Leukemia +

Acute Lymphoblastic Leukemia +

B-Cell Non-Hodgkin Lymphoma +

Hairy Cell Leukemia +

Leukemia +

Lymphoma +

Transformed Non-Hodgkin Lymphoma +

B-Cell Lymphoblastic Lymphoma +

Diffuse Large B-Cell Lymphoma +

Hairy Cell Leukemia Variant +

Non-Hodgkin Lymphoma +

Primary Mediastinal B-Cell Lymphoma +

Chronic Myeloid Leukemia +

Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation +

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma +

Acute Biphenotypic Leukemia +

Acute Leukemia +

B-Cell Neoplasm +

B-Cell Prolymphocytic Leukemia +

Burkitt Leukemia +

Chronic Lymphocytic Leukemia +

High Grade B-Cell Lymphoma With MYC And BCL2 And/Or BCL6 Rearrangements +

Hodgkin Lymphoma +

Mantle Cell Lymphoma +

Richter Syndrome +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.