Overview

Location [1]
9p24.1
Protein [2]
Programmed cell death 1 ligand 1
Synonyms [1]
PDCD1LG1, B7-H, PDCD1L1, PDL1, B7H1, PD-L1

CD274 molecule (CD274; also known as PDL1) is a gene that encodes a protein that is known as programmed cell death 1 ligand 1 (PD-L1). The protein functions in the transmission of the costimulatory signal that is needed for T-cell proliferation. Interaction with the protein inhibits T-cell activation and proliferation. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

CD274 is altered in 1.01% of all cancers with breast carcinoma, non-small cell lung carcinoma, colorectal adenocarcinoma, malignant glioma, and melanoma having the greatest prevalence of alterations [3].

CD274 GENIE Cases - Top Diseases

The most common alterations in CD274 are CD274 Mutation (0.37%), CD274 Amplification (0.32%), CD274 Loss (0.31%), CD274 R260H (0.02%), and CD274 R260C (0.01%) [3].

CD274 GENIE Cases - Top Alterations

Significance of CD274 in Diseases

Malignant Solid Tumor +

Gastric Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.