Location [1]
Protein [2]
CD276 antigen
Synonyms [1]
B7-H3, 4Ig-B7-H3, B7H3, B7RP-2

CD276 molecule (CD276) is a gene that encodes a protein that is a member of the immunoglobulin superfamily. The protein functions in the T-cell mediated immune response. Missense and silent mutations are observed in cancers such as eye cancer, skin cancer, and stomach cancer.

CD276 is altered in 0.08% of all cancers with breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

CD276 GENIE Cases - Top Diseases

The most common alterations in CD276 are CD276 Amplification (0.04%) and CD276 Loss (0.01%) [3].

CD276 GENIE Cases - Top Alterations

Significance of CD276 in Diseases

Malignant Solid Tumor +

Melanoma +

Breast Carcinoma +

Desmoplastic Small Round Cell Tumor +

Neuroblastoma +

Non-Small Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Osteosarcoma +

Primitive Neuroectodermal Tumor +

Prostate Carcinoma +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Rhabdomyosarcoma +

Wilms Tumor +

Bladder Carcinoma +

Colorectal Carcinoma +

Ewing Sarcoma +

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor +

Head And Neck Carcinoma +

Hepatoblastoma +

Malignant Central Nervous System Neoplasm +

Malignant Leptomeningeal Neoplasm +

Malignant Thyroid Gland Neoplasm +

Medulloblastoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

Urothelial Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.