Location [1]
Protein [2]
CD70 antigen
Synonyms [1]

CD70 molecule (CD70) is a gene that encodes a cytokine protein that functions as a ligand in the tumor necrosis factor (TNF) family. The protein functions in the induction of proliferation of co-stimulated T-cells. The protein also augments the generation of cytolytic T-cells and contributes to T-cell activation. Regulatory roles of the protein include the regulation of B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as bone cancer, intestinal cancer, and skin cancer.

CD70 is altered in 0.75% of all cancers with pancreatic adenocarcinoma, lung adenocarcinoma, bladder urothelial carcinoma, Burkitt lymphoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

CD70 GENIE Cases - Top Diseases

The most common alterations in CD70 are CD70 Amplification (1.42%), CD70 G78A (0.13%), CD70 A28V (0.08%), CD70 A42T (0.08%), and CD70 H107Y (0.08%) [3].

CD70 GENIE Cases - Top Alterations

Significance of CD70 in Diseases

Malignant Solid Tumor +

Diffuse Large B-Cell Lymphoma +

Mantle Cell Lymphoma +

Renal Cell Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.