Associated Genetic Biomarkers
CD70 molecule (CD70) is a gene that encodes a cytokine protein that functions as a ligand in the tumor necrosis factor (TNF) family. The protein functions in the induction of proliferation of co-stimulated T-cells. The protein also augments the generation of cytolytic T-cells and contributes to T-cell activation. Regulatory roles of the protein include the regulation of B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as bone cancer, intestinal cancer, and skin cancer.
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.