Location [1]
Immune checkpoints
Protein [2]
B-cell antigen receptor complex-associated protein alpha chain
Synonyms [1]

CD79a molecule, immunoglobulin-associated alpha (CD79A) is a gene that encodes the Ig-alpha protein. The protein functions as a component of the B-cell antigen that is a member of the B lymphocyte antigen receptor multimeric protein complex. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

CD79A is altered in 0.86% of all cancers with colon adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, endometrial endometrioid adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

CD79A GENIE Cases - Top Diseases

The most common alterations in CD79A are CD79A Mutation (0.37%), CD79A Loss (0.21%), CD79A Amplification (0.19%), CD79A X190_splice (0.03%), and CD79A V69I (0.02%) [3].

CD79A GENIE Cases - Top Alterations

Significance of CD79A in Diseases

Diffuse Large B-Cell Lymphoma +

Peripheral T-Cell Lymphoma, Not Otherwise Specified +

Head And Neck Squamous Cell Carcinoma +

Cancer +

Cervical Carcinoma +

Adult T-Cell Acute Lymphoblastic Leukemia +

Anaplastic Large Cell Lymphoma +

Angioimmunoblastic T-Cell Lymphoma +

Enteropathy-Associated T-Cell Lymphoma +

Follicular T-Cell Lymphoma +

Hepatosplenic T-Cell Lymphoma +

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma +

Mycosis Fungoides +

Nasal Type Extranodal NK/T-Cell Lymphoma +

Nodal Peripheral T-Cell Lymphoma With TFH Phenotype +

Peripheral T-Cell Lymphoma +

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma +

Sezary Syndrome +

Subcutaneous Panniculitis-Like T-Cell Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.