Cell division cycle 73 (CDC73) is a gene that encodes a protein that functions in transcriptional regulation and tumor suppression. Missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame deletions are observed in cancers such as bone cancer, intestinal cancer, and parathyroid cancer.
CDC73 is altered in 1.19% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and invasive breast carcinoma having the greatest prevalence of alterations .
The most common alterations in CDC73 are CDC73 Mutation (0.86%), CDC73 Amplification (0.23%), CDC73 R91Q (0.04%), CDC73 Loss (0.03%), and CDC73 R139Q (0.03%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.