Location [1]
Protein [2]
Synonyms [1]

Cadherin 1, type 1, E-cadherin (epithelial) (CDH1) is a gene that encodes a protein that functions as a calcium dependent cell-cell adhesion glycoprotein that mediates bacterial adhesion to mammalian cells. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame deletions and insertions are observed in cancers such as breast cancer, intestinal cancer, and stomach cancer.

CDH1 is altered in 3.13% of all cancers with breast invasive lobular carcinoma, breast invasive ductal carcinoma, invasive breast carcinoma, colon adenocarcinoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].

CDH1 GENIE Cases - Top Diseases

The most common alterations in CDH1 are CDH1 Mutation (1.88%), CDH1 Q23* (0.15%), CDH1 Loss (0.15%), CDH1 Amplification (0.09%), and CDH1 X522_splice (0.05%) [3].

CDH1 GENIE Cases - Top Alterations

Significance of CDH1 in Diseases

Lobular Breast Carcinoma +

Gastric Diffuse Adenocarcinoma +

Mixed Lobular And Ductal Breast Carcinoma +

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.