Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
10q21.2
Pathway
Cell cycle control
Protein [2]
Cyclin-dependent kinase 1
Synonyms [1]
P34CDC2, CDC28A, CDC2

Cyclin-dependent kinase 1 (CDK1) is a gene that encodes a member of the serine/threonine protein kinase family. The protein functions as a catalytic subunit of the protein kinase complex referred to as M-phase promoting factor (MPF). The protein plays a regulatory role in the cell cycle.

CDK1 is altered in 0.66% of all cancers with lung adenocarcinoma and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

CDK1 GENIE Cases - Top Diseases

The most common alterations in CDK1 are CDK1 Mutation (0.13%), CDK1 Amplification (0.03%), CDK1 Loss (0.01%), CDK1 R275* (0.01%), and CDK1 D262H (0.00%) [3].

CDK1 GENIE Cases - Top Alterations

Significance of CDK1 in Diseases

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.