Location [1]
Cell cycle control
Protein [2]
Cyclin-dependent kinase 2
Synonyms [1]
p33(CDK2), CDKN2

Cyclin-dependent kinase 2 (CDK2) is a gene that encodes a member of the serine/threonine protein kinase family that functions in cell cycle regulation. Specifically, the protein is important for the progression from G1 to S phase. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer.

CDK2 is altered in 0.16% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, conventional glioblastoma multiforme, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

CDK2 GENIE Cases - Top Diseases

The most common alterations in CDK2 are CDK2 Mutation (0.41%), CDK2 Amplification (0.06%), CDK2 R200W (0.03%), CDK2 E28K (0.02%), and CDK2 R199C (0.02%) [3].

CDK2 GENIE Cases - Top Alterations

Significance of CDK2 in Diseases

Malignant Solid Tumor +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Breast Carcinoma +

Gastric Carcinoma +

Esophageal Carcinoma +

Germ Cell Tumor +

Histiocytic And Dendritic Cell Neoplasm +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.