Overview

Location [1]
12q13.2
Pathway
Cell cycle control
Protein [2]
Cyclin-dependent kinase 2
Synonyms [1]
p33(CDK2), CDKN2

Cyclin-dependent kinase 2 (CDK2) is a gene that encodes a member of the serine/threonine protein kinase family that functions in cell cycle regulation. Specifically, the protein is important for the progression from G1 to S phase. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer.

CDK2 is altered in 0.50% of all cancers with non-small cell lung carcinoma, colorectal adenocarcinoma, malignant glioma, breast carcinoma, and uterine corpus neoplasm having the greatest prevalence of alterations [3].

CDK2 GENIE Cases - Top Diseases

The most common alterations in CDK2 are CDK2 Mutation (0.11%), CDK2 Amplification (0.01%), CDK2 R200W (0.01%), CDK2 R199C (0.00%), and CDK2 R199H (0.00%) [3].

CDK2 GENIE Cases - Top Alterations

Significance of CDK2 in Diseases

Malignant Solid Tumor +

Non-Hodgkin Lymphoma +

Gastric Carcinoma +

Colorectal Carcinoma +

Clear Cell Renal Cell Carcinoma +

Breast Carcinoma +

Cholangiocarcinoma +

Esophageal Carcinoma +

Germ Cell Tumor +

Histiocytic And Dendritic Cell Neoplasm +

Mesothelioma +

Uveal Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.