Overview

Location [1]
12q13.2
Pathway
Cell cycle control
Synonyms [1]
CDKN2, p33(CDK2)

Cyclin-dependent kinase 2 (CDK2) is a gene that encodes a member of the serine/threonine protein kinase family that functions in cell cycle regulation. Specifically, the protein is important for the progression from G1 to S phase. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer.

Significance of CDK2 in Diseases

Malignant Solid Tumor +

Non-Hodgkin Lymphoma +

Breast Carcinoma +

Colorectal Carcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Germ Cell Tumor +

Histiocytic And Dendritic Cell Neoplasm +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.