Cyclin-dependent kinase 8 (CDK8) is a gene that encodes a protein that is a member of the cyclin-dependent protein kinase family. The protein functions in the phosphorylation of the C-terminal of the large subunit of RNA polymerase II (transcriptional regulation). Missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and lung cancer.
CDK8 is altered in 1.08% of all cancers with colon adenocarcinoma, lung adenocarcinoma, rectal adenocarcinoma, bladder urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations .
The most common alterations in CDK8 are CDK8 Mutation (0.65%), CDK8 Amplification (0.35%), CDK8 Loss (0.09%), CDK8 S62L (0.03%), and CDK8 R71* (0.03%) .
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3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.