Location [1]
Cell cycle control
Protein [2]
Cyclin-dependent kinase 8
Synonyms [1]

Cyclin-dependent kinase 8 (CDK8) is a gene that encodes a protein that is a member of the cyclin-dependent protein kinase family. The protein functions in the phosphorylation of the C-terminal of the large subunit of RNA polymerase II (transcriptional regulation). Missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and lung cancer.

CDK8 is altered in 1.08% of all cancers with colon adenocarcinoma, lung adenocarcinoma, rectal adenocarcinoma, bladder urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

CDK8 GENIE Cases - Top Diseases

The most common alterations in CDK8 are CDK8 Mutation (0.65%), CDK8 Amplification (0.35%), CDK8 Loss (0.09%), CDK8 S62L (0.03%), and CDK8 R71* (0.03%) [3].

CDK8 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.