Overview

Location [1]
12p13.1
Pathway
Cell cycle control
Synonyms [1]
P27KIP1, MEN4, KIP1, CDKN4, MEN1B

Cyclin-dependent kinase inhibitor 1B (CDKN1B, also known as p27) is a gene that encodes a protein that binds to and inhibits the activation of cyclin E/CDK2 or cyclin D/CDK4 complexes in order to regulate cell cycle progression at G1. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, esophageal cancer, and intestinal cancer.

Significance of CDKN1B in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Anaplastic Astrocytoma +

Bladder Carcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Germ Cell Tumor +

Glioblastoma +

Head And Neck Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Lymphoma +

Melanoma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.