Overview

Location [1]
12p13.31
Synonyms [1]
CHD-4, Mi-2b, Mi2-BETA, SIHIWES

Chromodomain helicase DNA binding protein 4 (CHD4) is a gene that encodes a protein that is the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Missense mutations, synonymous mutations, nonsense mutations, inframe deletions, frameshift deletions, and frameshift insertions are observed in cancers such as stomach cancer, endometrial cancer, and colon cancer.

Significance of CHD4 in Diseases

Anaplastic Astrocytoma +

Bladder Carcinoma +

Breast Carcinoma +

Colorectal Carcinoma +

Glioblastoma +

Head And Neck Carcinoma +

Lymphoma +

Malignant Solid Tumor +

Melanoma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.