Overview

Location [1]
12p13.31
Protein [2]
Chromodomain-helicase-DNA-binding protein 4
Synonyms [1]
Mi-2b, SIHIWES, Mi2-BETA, CHD-4

Chromodomain helicase DNA binding protein 4 (CHD4) is a gene that encodes a protein that is the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Missense mutations, synonymous mutations, nonsense mutations, inframe deletions, frameshift deletions, and frameshift insertions are observed in cancers such as stomach cancer, endometrial cancer, and colon cancer.

CHD4 is altered in 4.05% of all cancers with colorectal adenocarcinoma, breast carcinoma, melanoma, malignant glioma, and bladder carcinoma having the greatest prevalence of alterations [3].

CHD4 GENIE Cases - Top Diseases

The most common alterations in CHD4 are CHD4 Mutation (0.15%), CHD4 Amplification (0.02%), CHD4 D1139Y (0.00%), CHD4 D1237V (0.00%), and CHD4 D1358_D1361del (0.00%) [3].

CHD4 GENIE Cases - Top Alterations

Significance of CHD4 in Diseases

Bladder Carcinoma +

Colorectal Carcinoma +

Malignant Solid Tumor +

Anaplastic Astrocytoma +

Melanoma +

Head And Neck Carcinoma +

Breast Carcinoma +

Glioblastoma +

Non-Small Cell Lung Carcinoma +

Lymphoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.