Location [1]
Protein [2]
Protein capicua homolog
Synonyms [1]

Capicua transcriptional repressor (CIC) is a gene that encodes a protein that is included in the high mobility group (HMG)-box family and functions as a repressor of transcription. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame deletions are observed in cancers such as central nervous system cancers, fallopian tube cancers, and intestinal cancer.

CIC is altered in 3.03% of all cancers with colon adenocarcinoma, lung adenocarcinoma, oligodendroglioma, endometrial endometrioid adenocarcinoma, and anaplastic oligodendroglioma having the greatest prevalence of alterations [3].

CIC GENIE Cases - Top Diseases

The most common alterations in CIC are CIC Loss (0.20%), CIC Amplification (0.19%), CIC Fusion (0.08%), CIC P1248fs (0.07%), and CIC P1597fs (0.07%) [3].

CIC GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.