Biomarkers /

CLCN6

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Overview

Location [1]
1p36.22
Protein [2]
Chloride transport protein 6
Synonyms [1]
CLC-6

CLCN6 is altered in 0.06% of all cancers with low-grade glioma, NOS, pancreatic adenocarcinoma, pilocytic astrocytoma, thyroid gland papillary carcinoma, and astrocytoma having the greatest prevalence of alterations [3].

CLCN6 GENIE Cases - Top Diseases

The most common alterations in CLCN6 are CLCN6-BRAF Fusion (0.14%) and CLCN6-BAP1 Fusion (0.00%) [3].

CLCN6 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.