Biomarkers /

CLK3

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Overview

Location [1]
15q24.1
Protein [2]
Dual specificity protein kinase CLK3
Synonyms [1]
PHCLK3, PHCLK3/152

CLK3 is altered in 1.32% of all cancers with breast invasive ductal carcinoma, mixed lobular and ductal breast carcinoma, breast invasive lobular carcinoma, and breast neoplasm having the greatest prevalence of alterations [3].

CLK3 GENIE Cases - Top Diseases

The most common alterations in CLK3 are CLK3 Amplification (0.58%), CLK3 C266Y (0.04%), CLK3 D372H (0.04%), CLK3 E221K (0.04%), and CLK3 E456del (0.04%) [3].

CLK3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.