Clathrin, heavy chain-like 1 (CLTCL1) is a gene that encodes a protein that is a component of the polyhedral coat of coated pits and vesicles. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
CLTCL1 is altered in 0.17% of all cancers with lung adenocarcinoma, pancreatic adenocarcinoma, colon adenocarcinoma, acute myeloid leukemia, and anaplastic meningioma having the greatest prevalence of alterations .
The most common alterations in CLTCL1 are CLTCL1-ALK Fusion (0.08%), CLTCL1 A238V (0.30%), CLTCL1 E1009D (0.30%), CLTCL1 E1388* (0.30%), and CLTCL1 E1628Q (0.30%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.