Centriolin (CNTRL; also known as CEP110) is a gene that encodes a centrosomal protein that functions as a microtubule organizing center. Fusions, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as Hematopoietic and lymphoid cancers, lung cancer, and ovarian cancer.
CNTRL is altered in 0.09% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, prostate adenocarcinoma, dysembryoplastic neuroepithelial tumor, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations .
The most common alteration in CNTRL is CNTRL-FGFR1 Fusion (0.22%) .
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