Location [1]
Protein [2]
Cyclic AMP-responsive element-binding protein 1
Synonyms [1]

cAMP responsive element binding protein 1 (CREB1) is a gene that encodes a protein that is a transcription factor in the leucine zipper family of DNA binding proteins. Fusions, missense mutations, silent mutations, and nonsense mutations are observed in cancers such as upper aerodigestive tract cancer, breast cancer, and central nervous system cancers.

CREB1 is altered in 0.08% of all cancers with clear cell sarcoma of soft tissue, colorectal adenocarcinoma, sarcoma, NOS, unknown, and poorly differentiated carcinoma, NOS having the greatest prevalence of alterations [3].

CREB1 GENIE Cases - Top Diseases

The most common alterations in CREB1 are CREB1-EWSR1 Fusion (0.01%), CREB1 A190S (0.22%), CREB1 A213T (0.22%), CREB1 A296G (0.22%), and CREB1 D116G (0.09%) [3].

CREB1 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.