Overview

Location [1]
11p11.2
Protein [2]
Processed cyclic AMP-responsive element-binding protein 3-like protein 1
Synonyms [1]
OASIS, OI16

cAMP responsive element binding protein 3-like 1 (CREB3L1) is a gene that encodes a protein that functions in the membrane of the endoplasmic reticulum. Under stress, the protein is cleaved and the releases cytoplasmic transcription factor domain enters the nucleus. Subsequently, the transcription factor domain activates the transcription of target genes. Fusions, missense mutations, nonsense mutations, silent mutations, nonstop extensions, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

CREB3L1 is altered in 0.09% of all cancers with sclerosing epithelioid fibrosarcoma, lung adenocarcinoma, breast invasive ductal carcinoma, glioblastoma, and fibrosarcoma having the greatest prevalence of alterations [3].

CREB3L1 GENIE Cases - Top Diseases

The most common alteration in CREB3L1 is CREB3L1-EWSR1 Fusion (0.02%) [3].

CREB3L1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.