CREB regulated transcription coactivator 1 (CRTC1) is a gene that encodes a protein that functions as a transcriptional coactivator. Fusions, missense mutations, silent mutations, frameshift deletions, frameshift insertions, and nonsense mutations are observed in cancers such as colon cancer, skin cancer, and stomach cancer.
CRTC1 is altered in 0.82% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and melanoma having the greatest prevalence of alterations .
The most common alterations in CRTC1 are CRTC1 Mutation (1.22%), CRTC1-MAML2 Fusion (0.11%), CRTC1 Fusion (0.09%), CRTC1-TRIM11 Fusion (0.09%), and CRTC1 K197R (0.06%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.