CTLA4 is altered in 0.51% of all cancers with colon adenocarcinoma, endometrial endometrioid adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, and melanoma having the greatest prevalence of alterations .
The most common alterations in CTLA4 are CTLA4 Mutation (0.38%), CTLA4 Loss (0.04%), CTLA4 Amplification (0.03%), CTLA4 R75W (0.01%), and CTLA4 A54T (0.01%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.