Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
10q21.3
Protein [2]
Catenin alpha-3
Synonyms [1]
ARVD13, VR22

CTNNA3 is altered in 0.17% of all cancers with breast invasive ductal carcinoma, mixed lobular and ductal breast carcinoma, breast neoplasm, breast invasive lobular carcinoma, and ganglioglioma having the greatest prevalence of alterations [3].

CTNNA3 GENIE Cases - Top Diseases

The most common alterations in CTNNA3 are CTNNA3 Mutation (1.45%), CTNNA3 Amplification (0.70%), CTNNA3 Loss (0.54%), CTNNA3 I411V (0.08%), and CTNNA3 M435V (0.08%) [3].

CTNNA3 GENIE Cases - Top Alterations

Significance of CTNNA3 in Diseases

Medulloblastoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.