Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Catenin alpha-3
Synonyms [1]
VR22, ARVD13

CTNNA3 is altered in 1.62% of all cancers with breast invasive ductal carcinoma, breast neoplasm, and mixed lobular and ductal breast carcinoma having the greatest prevalence of alterations [3].

CTNNA3 GENIE Cases - Top Diseases

The most common alterations in CTNNA3 are CTNNA3 Mutation (0.07%), CTNNA3 Amplification (0.04%), CTNNA3 Loss (0.03%), CTNNA3 I411V (0.00%), and CTNNA3 M435V (0.00%) [3].

CTNNA3 GENIE Cases - Top Alterations

Significance of CTNNA3 in Diseases

Medulloblastoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.