Biomarkers /
CTNNB1
Overview
CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa) is a gene that encodes catenin beta-1 protein (also known as beta-catenin). beta-catenin is part of a complex of proteins that form adherens junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells (PMID: 17854762). Mutant beta-catenin has been implicated in the pathogenesis of several cancers including melanoma, colorectal cancer, hepatocelluar carcinoma, and ovarian cancer (PMID: 12781368).
CTNNB1 is altered in 3.10% of all cancers with endometrial endometrioid adenocarcinoma, lung adenocarcinoma, colon adenocarcinoma, prostate adenocarcinoma, and hepatocellular carcinoma having the greatest prevalence of alterations [3].
The most common alterations in CTNNB1 are CTNNB1 Mutation (2.82%), CTNNB1 S37F (0.34%), CTNNB1 S45F (0.21%), CTNNB1 T41A (0.19%), and CTNNB1 S45P (0.17%) [3].
Clinical Trials
Significance of CTNNB1 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.