Cut-like homeobox 1 (CUX1) is a gene that encodes a protein that belongs to the homeodomain family of DNA binding proteins. The protein functions in the regulation of gene expression, morphogenesis, and differentiation. The protein may also regulate cell cycle progression. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift insertions and deletions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.
CUX1 is altered in 1.94% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations .
The most common alterations in CUX1 are CUX1-FGFR1 Fusion (0.27%), CUX1-BRAF Fusion (0.17%), CUX1-ALK Fusion (0.13%), CUX1 Amplification (0.09%), and CUX1 Loss (0.07%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.