Biomarkers /

CXCR4

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Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
2q22.1
Synonyms [1]
WHIM, FB22, WHIMS, NPYY3R, HSY3RR, D2S201E, LESTR, HM89, LAP3, NPYR, NPY3R, LCR1, LAP-3, CD184, NPYRL

Chemokine (C-X-C motif) receptor 4 (CXCR4) is a gene that encodes a protein that functions as a chemokine receptor that is specific for stromal cell-derived factor 1. The protein, along with the CD4 protein, supports HIV entry into cells. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

Clinical Trials

View Clinical Trials for CXCR4

Significance of CXCR4 in Diseases

Waldenstrom Macroglobulinemia +

Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome (WHIMS) +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.