Associated Genetic Biomarkers
Cylindromatosis (turban tumor syndrome) (CYLD) is a gene that encodes a protein that functions as a deubiquitinating enzyme. Missense mutations, silent mutations, nonsense mutations, frameshift deletions, and frameshift insertions are observed in cancers such as skin cancer, colon cancer, and endometrial cancer.
CYLD is altered in 1.55% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations .
The most common alterations in CYLD are CYLD Mutation (1.27%), CYLD Loss (0.18%), CYLD Amplification (0.11%), CYLD N722fs (0.07%), and CYLD S371* (0.04%) .
CYLD status serves as an inclusion eligibility criteria in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial that contains CYLD status as an inclusion criterion, 1 is phase 1 (0 open).
Trials with CYLD status in the inclusion eligibility criteria most commonly target bladder carcinoma, breast carcinoma, colorectal carcinoma, head and neck carcinoma, and lymphoma .
The most frequent alterations to serve as inclusion eligibility criteria are CYLD Loss and CYLD Mutation .
Extended release flucytosine and vocimagene amiretrorepvec are the most frequent therapies in trials with CYLD as an inclusion criteria .
Significance of CYLD in Diseases
Head And Neck Carcinoma +
Colorectal Carcinoma +
Non-Small Cell Lung Carcinoma +
CYLD is altered in 1.81% of non-small cell lung carcinoma patients .
CYLD is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 0 are open and 1 is closed. Of the trial that contains CYLD status and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (0 open) .
Bladder Carcinoma +
Anaplastic Astrocytoma +
Malignant Solid Tumor +
Ovarian Carcinoma +
Breast Carcinoma +
Pancreatic Carcinoma +
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.