Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
13q14.2
Protein [2]
Cysteinyl leukotriene receptor 2
Synonyms [1]
HPN321, HG57, CYSLT2R, hGPCR21, KPG_011, CYSLT2, GPCR21, PSEC0146

CYSLTR2 is altered in 1.18% of all cancers with prostate adenocarcinoma, lung adenocarcinoma, colon adenocarcinoma, uterine corpus leiomyosarcoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

CYSLTR2 GENIE Cases - Top Diseases

The most common alterations in CYSLTR2 are CYSLTR2 Loss (0.26%), CYSLTR2 Mutation (0.14%), CYSLTR2 Amplification (0.02%), CYSLTR2 E343K (0.01%), and CYSLTR2 P325S (0.00%) [3].

CYSLTR2 GENIE Cases - Top Alterations

Significance of CYSLTR2 in Diseases

Melanoma +

Uveal Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.