Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Cysteinyl leukotriene receptor 2
Synonyms [1]
GPCR21, hGPCR21, CYSLT2R, HG57, KPG_011, PSEC0146, HPN321, CYSLT2

CYSLTR2 is altered in 1.58% of all cancers with prostate adenocarcinoma, lung adenocarcinoma, colon adenocarcinoma, uterine corpus leiomyosarcoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

CYSLTR2 GENIE Cases - Top Diseases

The most common alterations in CYSLTR2 are CYSLTR2 Loss (0.94%), CYSLTR2 Mutation (0.53%), CYSLTR2 Amplification (0.08%), CYSLTR2 E343K (0.02%), and CYSLTR2 R136H (0.02%) [3].

CYSLTR2 GENIE Cases - Top Alterations

Significance of CYSLTR2 in Diseases

Uveal Melanoma +

Melanoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.