Location [1]
Protein [2]
Death domain-associated protein 6
Synonyms [1]

Death domain associated protein (DAXX) is a gene that encodes a protein that functions in transcriptional repression and apoptosis. Missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame deletions are observed in cancers such as adrenal cancer, intestinal cancer, and stomach cancer.

DAXX is altered in 1.45% of all cancers with pancreatic neuroendocrine neoplasm, lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

DAXX GENIE Cases - Top Diseases

The most common alterations in DAXX are DAXX Mutation (1.25%), DAXX Amplification (0.17%), DAXX Frameshift (0.13%), DAXX Nonsense (0.14%), and DAXX Loss (0.04%) [3].

DAXX GENIE Cases - Top Alterations

Significance of DAXX in Diseases

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.