Biomarkers /

DCC

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Overview

Location [1]
18q21.2
Protein [2]
Netrin receptor DCC
Synonyms [1]
IGDCC1, CRCR1, HGPPS2, CRC18, MRMV1, NTN1R1

DCC is altered in 0.59% of all cancers with melanoma, cutaneous melanoma, conventional glioblastoma multiforme, high grade ovarian serous adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

DCC GENIE Cases - Top Diseases

The most common alterations in DCC are DCC R1025Q (0.33%), DCC E403K (0.28%), DCC G1294R (0.31%), DCC R1337* (0.18%), and DCC R446H (0.19%) [3].

DCC GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.