DCC is altered in 0.59% of all cancers with melanoma, cutaneous melanoma, conventional glioblastoma multiforme, high grade ovarian serous adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations .
The most common alterations in DCC are DCC R1025Q (0.33%), DCC E403K (0.28%), DCC G1294R (0.31%), DCC R1337* (0.18%), and DCC R446H (0.19%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.