Biomarkers /

DCTN1

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Associated Diseases

Overview

Location [1]
2p13.1
Protein [2]
Dynactin subunit 1
Synonyms [1]
DP-150, P135, DAP-150

DCTN1 is altered in 0.04% of all cancers with lung adenocarcinoma, acute myeloid leukemia, cancer of unknown primary, diffuse large B-cell lymphoma, not otherwise specified, and glioblastoma having the greatest prevalence of alterations [3].

DCTN1 GENIE Cases - Top Diseases

The most common alteration in DCTN1 is DCTN1-ALK Fusion (0.04%) [3].

DCTN1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.